Seed Saving : Lettuce Lettuce is also a wonderful seed saving project for the beginner. Lettuce is very rare to cross pollinate, they have perfect flowers which pollinate themselves before the flower opens. It seems that all lettuces are OP and are not hybrids. I could be wrong on this, but I have never seen one. As a precaution you may want to separate lettuces you are saving seed from by 25 feet. Allow plants to bolt and go to seed, but pull and discard the early bolters, otherwise you are breeding that tendancy for early bolting into your 'custom made seeds'. Bag bolting seed heads with paper bags to prevent bird and rain damage. Seeds are produced over a 2-3 week period and may require repeated picking. tenzicut - who hopes that if she cant save Open Pollinated seed this year, she may inspire someone else to.